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Research Registry No |
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PLRID-00453_V2 |
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Postgraduate Research |
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University Departmental Research |
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yes |
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Registration Date |
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2019-07-29 |
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Principle Investigator |
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Aye Aye Khin |
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Co-Investigators |
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Dr. Naw Hser Gay, Department of Medical Laboratoy Technology, University of Medical Technology, Yang, Khin Aye Thin, Department of Medical Laboratoy Technology, University of Medical Technology, Yangon., Aye Thinzar Win, National Health Laboratory, Yangon. |
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Title of Research |
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Association of vWF Factor levels and ABO blood group in Blood Donors |
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Field of Research |
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Pathology |
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Preliminary Research Design |
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Descriptive Study |
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Preliminary Research Type |
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Basic |
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Preliminary Justification |
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The hypothesis that ABO blood group influences the rate of biosynthesis/secretion of vWF in endothelial cells is difficult to study, as glycan structures of vWF synthesized in vitro differ significantly from those of plasma vWF. However, a more probable explanation for reduced vWF levels in blood group O individuals involves a decreased survival. A number of studies have demonstrated a relationship between ABO blood group and hemostasis. Indeed, a higher rate of bleeding complications has been presented in group O patients and blood group O individuals are found in patients with inherited bleeding disorders . On the other hand, the relationship between non-O blood groups and the risk of arterial thrombosis has been recognized(Franchini et al.,2007, Mohamed,2017). Therefore, the aim of the present study was to identify possible associations between ABO blood group types and plasma levels of vWF in blood donors in order to improve potential links between blood type and bleeding disorders as well as in the context of clinical implications such as predicting the risk of adverse outcome by using vWF as indicator. |
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Preliminary Aim |
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This study aims to explore association between von Willebrand factor levels and ABO blood groups in blood donors |
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Preliminary Objectives |
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1. To identify ABO blood groups in blood donors 2. To measure plasma von Willebrand factor levels in blood donors 3. To find out association between von Willebrand factor levels and ABO blood groups in blood donors |
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Preliminary Sample Size |
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100 |
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Preliminary Study Duration |
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one year |
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Preliminary Study Area |
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Yangon |
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Preliminary Study Method |
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Convenience sampling method |
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Preliminary Research Outcome |
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Not finished yet |
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Preliminary Research Finding |
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Not finished yet |
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Preliminary Progress Report |
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20 samples have been collected. |
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Study Starting Date |
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2019-07-05 |
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IRB/PRC/ERC Approval Date |
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2019-02-28 |
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Placement of IRB/PRC/ERC |
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University of Medical Technology |
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IRB/PRC/ERC Approval Letter/Document |
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ethical.pdf |
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Pre-existing Registration ID |
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- |
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Pre-existing Name of Organization |
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- |
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Pre-existing Name of Organization Website |
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