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Research Registry No |
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PLRID-00527_V6 |
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Postgraduate Research |
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No |
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University Departmental Research |
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Yes |
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Name of University |
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University of Medicine 1, Yangon |
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Department |
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Department of Neurology |
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Registration Date |
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2020-02-06 |
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Principle Investigator |
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WIN MIN THIT |
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Co-Investigators |
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THAN WIN NYUNT, SAN OO, OHNMAR, YIN MINN AYE, ZARNI MYINT SHWE, KHIN MYAT PO PO KYAW, SOE THINZAR OO |
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Title of Research |
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Apolipoprotein E genotyping in Alzheimer's disease and other dementia disorders |
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Field of Research |
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Neurology |
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Preliminary Research Design |
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Descriptive Study |
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Preliminary Research Type |
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Applied |
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Preliminary Justification |
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Although increasing burden of dementia globally, the prevalence of dementia is still underestimated in developing countries because of lack of knowledge and awareness. The morbidity from dementia in Myanmar is also high. However, there is no accurate data on prevalence of various subtypes of dementia and its risk factors including genetic factors. Therefore, there is an essential need to conduct focused research to estimates prevalence of dementia and its subtypes in order to give better care of patients, to help reduce the morbidity, and to take measures for better prevention and control strategies.
This study will be a fundamental research in predicting the prevalence of dementia in Myanmar as study area is a tertiary center receiving patients from different parts of the country. Based on the results of this study, estimates prevalence of subtypes of dementia and its risk factors in Myanmar will be known and patients can be get accurate care and subsequently reduce morbidity and burden of caregivers. |
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Preliminary Aim |
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To study the prevalence of dementia in elderly persons and association with age, gender, education, and apolipoprotein E genotype |
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Preliminary Objectives |
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1. To estimate the incidence of dementia and its clinical subtypes among elderly persons in Yangon General Hospital 2. To determine the association of dementia with age, gender, education, and apolipoprotein E genotype |
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Preliminary Sample Size |
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Elderly patients aged 65 years or older with symptom of cognitive functions who admitted at Memory outpatient clinic, Neurology Department, and Geriatric Department of Yangon General Hospital will be consecutively recruited. Estimated sample size is about 50 participants. |
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Preliminary Study Duration |
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Six months |
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Preliminary Study Area |
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Memory outpatient clinic, Neurology Department and Geriatric department of Yangon General Hospital |
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Preliminary Study Method |
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Descriptive, hospital-based cross-sectional study |
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Preliminary Research Outcome |
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Demographic information, MMSE, MoCHA test, Prevalence of dementia patients, subtypes of dementia, blood tests, APOE genotype, Brain CT/MRI |
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Preliminary Research Finding |
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1) Diagnosis of dementia - Dementia will be diagnosed according to DSM-IV criteria. 2) Cognitive test battery comprising Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) in own language will done. 3) APOE Genotyping: 5 ml bloo |
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Preliminary Progress Report |
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This study was started in August 2019. During this study period, 20 dementia patients were collected according to inclusion criteria. Among study population, mean age was 67  1.26 years and male was 14(70%) and female was 6(30%). Most of the patients c |
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Study Starting Date |
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2019-08-07 |
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IRB/PRC/ERC Approval Date |
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2019-08-07 |
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Placement of IRB/PRC/ERC |
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University of Medicine 1, Yangon |
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IRB/PRC/ERC Approval Letter/Document |
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060220200603382019DementiaApoE.pdf |
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Pre-existing Registration ID |
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031/UM1,REC.2019 |
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Pre-existing Name of Organization |
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Department of Neurology |
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Pre-existing Name of Organization Website |
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