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Research Registry No |
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PLRID-00668_V3 |
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Postgraduate Research |
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No |
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University Departmental Research |
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Yes |
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Name of University |
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University of Dental Medicine,Mandalay |
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Department |
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Department of Periodontology |
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Registration Date |
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2020-12-04 |
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Principle Investigator |
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Thaw Htet Zin |
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Co-Investigators |
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Kyaw Thiha , Ommar Soe, Ye Myat Hein, Hein Min Zaw |
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Title of Research |
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Estimation of enzyme aspartate aminotransferase (AST) level from gingival crevicular fluid in patients with chronic gingivitis and chronic periodontitis |
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Field of Research |
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Dentistry |
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Preliminary Research Design |
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Analytic Study |
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Preliminary Research Type |
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Applied |
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Preliminary Justification |
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Today, there has been distinguishing among the various periodontal diseases in general presents little difficulty. With some exceptions, such as diagnosing refractory disease, a correct diagnosis can be made on the basis of the usual clinical and radiographic manifestations, history, and age of onset. The remaining problems, those of disease activity and host susceptibility, are not so readily resolved. Because none of the procedures traditionally used can distinguish between disease-active and inactive sites at a given point in time. By the use of these techniques, it is hoped that treatment will become more effective, and inappropriate treatment will be avoided thus resulting in more cost-effective outcome. In the search for a useful biochemical marker to assess disease activity, It is hope that AST, as a direct measure of tissue damage will prove to be a useful adjunct in the diagnosis of active periodontitis and ultimately aid in the design of more effective therapy Hence, this clinical study of quantitative estimation of AST levels in GCF in may assist to find the reliability as a diagnostic marker in gingivitis and periodontitis and which will help in the determination of disease activity, prevention and treatment for periodontal diseases. |
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Preliminary Aim |
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To estimate aspartate aminotransferase (AST) enzyme levels from gingival crevicular fluid in patients with chronic gingivitis and chronic periodontitis |
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Preliminary Objectives |
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1. To measure the periodontal clinical parameters: Gingival index (GI), Papillary Bleeding Index (PBI), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL) at healthy, chronic gingivitis and chronic periodontitis subjects 2. To determine enzyme aspartate aminotransferase (AST) level in gingival crevicular fluid at healthy, chronic gingivitis and chronic periodontitis subjects 3. To compare aspartate aminotransferase (AST) enzyme levels in GCF among healthy, chronic gingivitis and chronic periodontitis subjects 4. To correlate aspartate aminotransferase (AST) enzyme levels in GCF and periodontal clinical parameters (GI, PBI, PPD, CAL) in chronic gingivitis and chronic periodontitis subjects. |
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Preliminary Sample Size |
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180 teeth from 45 subjects will be selected for this research |
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Preliminary Study Duration |
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6 months |
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Preliminary Study Area |
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Department of Periodontology, University of Dental Medicine, Mandalay |
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Preliminary Study Method |
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Simple random sampling method |
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Preliminary Research Outcome |
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Enzyme aspartate aminotransferase (AST) level from gingival crevicular fluid chronic gingivitis and chronic periodontitis subjects are higher than that of healthy subjects |
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Preliminary Research Finding |
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Enzyme aspartate aminotransferase (AST) level from gingival crevicular fluid chronic periodontitis subjects are higher than that of healthy subjects |
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Preliminary Progress Report |
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According to recorded data, enzyme aspartate aminotransferase (AST) level from gingival crevicular fluid chronic periodontitis subjects are higher than that of healthy subjects |
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Study Starting Date |
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2020-07-01 |
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IRB/PRC/ERC Approval Date |
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2020-06-23 |
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Placement of IRB/PRC/ERC |
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University of Dental Medicine,Mandalay |
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IRB/PRC/ERC Approval Letter/Document |
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04122020074553ERC-AST.pdf |
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Pre-existing Registration ID |
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- |
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Pre-existing Name of Organization |
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- |
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Pre-existing Name of Organization Website |
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