Health Research Registry List

Research Registry No : HRID-00046_V6
 
University Departmental Research :
 
Registration Date : 2019-05-20
 
Title of Research : Comparison of Clinical and Virological Characteristics among Infants, Children and Adults with Dengue Infection during 2015 Dengue Outbreak
 
Principle Investigator : Theingi Win Myat
 
Co-authors : Dr. Hlaing Myat Thu, Professor Ye Myint Kyaw, Professor Hlaing Mya Win
 
Field of Research : Virology
 
Publication Source : Myanmar Health Sciences Research Journal, Vol. 30, No. 3, 2018
 
 
Year of Publication : 2018
 
URL of Publication : http://www.myanmarhsrj.com
 
Presentation Source : 45th Myanmar Helath Research Congress, 2017;
 
Placement of Presentation : Department of Medical Research
 
Year of Presentation : 2017
 
Abstract : Dengue is one of the important causes of serious illness and death in children. Recently, dengue hemorrhagic fever dengue shock syndrome was reported to occur in infants and a shift to older age group was also reported from many countries. In Myanmar, dramatic increase in hospitalization of dengue cases was noticed starting from June, 2015 in all ages and was regarded as an outbreak year. Therefore, this study was conducted with the aim to determine and compare the clinical and virological characteristics of dengue infection in infants, children and adults during 2015 outbreak. A total of 682 blood samples were collected from clinically diagnosed dengue patients admitted to Yangon Children’s Hospital and Yangon General Hospital between June and October, 2015. Among them, 25/43 (58%), 317/548 (58%) and 44/91 (48%) were serologically confirmed dengue infections in infants, children and adults, respectively. Secondary dengue infection was more common in adults (66%) whereas primary dengue infection accounted up to 88% in infants and the association is statistically significant (p<0.05). Regarding age distribution, 6-9 months group within infants (76%), 5-9 years group within children (53%) and 13-19 years group within adults (66%) were significantly higher than other age groups. The highest proportion of infant cases was DHF I (88%), whereas that of adults was DHF II (48%) and DSS accounted up to 27% in children. Upon serotyping by virus isolation and Reverse Transcriptase PCR method, virus was detected in 28 samples. Among them, 21(75%) was DENV 1, 2(7%) was DENV 2, 1(4%) was DENV 3 and 4(14%) was mixed serotypes. DENV 1 was more frequent in DHF I and II cases and all DENV 2 detected were from DSS cases. Key words: Dengue infection, Clinical characteristics of dengue, Dengue serotype, Adult dengue, Infant dengue
 
 
IRB/PRC/ERC Approval Date : 2015-06-02
 
Placement of IRB/PRC/ERC : Department of Medical Research
 
IRB/PRC/ERC Approval Letter/Document : ERC certificate.doc
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -