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Research Registry No |
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HRID-00046_V6 |
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University Departmental Research |
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Registration Date |
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2019-05-20 |
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Title of Research |
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Comparison of Clinical and Virological Characteristics among Infants,
Children and Adults with Dengue Infection during 2015 Dengue Outbreak |
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Principle Investigator |
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Theingi Win Myat |
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Co-authors |
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Dr. Hlaing Myat Thu, Professor Ye Myint Kyaw, Professor Hlaing Mya Win |
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Field of Research |
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Virology |
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Publication Source |
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Myanmar Health Sciences Research Journal, Vol. 30, No. 3, 2018 |
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Year of Publication |
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2018 |
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URL of Publication |
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http://www.myanmarhsrj.com |
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Presentation Source |
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45th Myanmar Helath Research Congress, 2017; |
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Placement of Presentation |
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Department of Medical Research |
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Year of Presentation |
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2017 |
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Abstract |
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Dengue is one of the important causes of serious illness and death in
children. Recently, dengue hemorrhagic fever dengue shock syndrome was
reported to occur in infants and a shift to older age group was also reported
from many countries. In Myanmar, dramatic increase in hospitalization of
dengue cases was noticed starting from June, 2015 in all ages and was
regarded as an outbreak year. Therefore, this study was conducted with the
aim to determine and compare the clinical and virological characteristics of
dengue infection in infants, children and adults during 2015 outbreak.
A total of 682 blood samples were collected from clinically diagnosed
dengue patients admitted to Yangon Children’s Hospital and Yangon
General Hospital between June and October, 2015. Among them, 25/43
(58%), 317/548 (58%) and 44/91 (48%) were serologically confirmed
dengue infections in infants, children and adults, respectively. Secondary
dengue infection was more common in adults (66%) whereas primary
dengue infection accounted up to 88% in infants and the association is
statistically significant (p<0.05). Regarding age distribution, 6-9 months
group within infants (76%), 5-9 years group within children (53%) and
13-19 years group within adults (66%) were significantly higher than other
age groups. The highest proportion of infant cases was DHF I (88%),
whereas that of adults was DHF II (48%) and DSS accounted up to 27%
in children. Upon serotyping by virus isolation and Reverse Transcriptase
PCR method, virus was detected in 28 samples. Among them, 21(75%) was
DENV 1, 2(7%) was DENV 2, 1(4%) was DENV 3 and 4(14%) was mixed
serotypes. DENV 1 was more frequent in DHF I and II cases and all
DENV 2 detected were from DSS cases.
Key words: Dengue infection, Clinical characteristics of dengue, Dengue serotype, Adult dengue, Infant dengue |
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IRB/PRC/ERC Approval Date |
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2015-06-02 |
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Placement of IRB/PRC/ERC |
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Department of Medical Research |
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IRB/PRC/ERC Approval Letter/Document |
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ERC certificate.doc
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Pre-existing Registration ID |
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- |
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Pre-existing Name of Organization |
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- |
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Pre-existing Website |
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