Health Research Registry List

Research Registry No : HRID-00046_V7
University Departmental Research :
Registration Date : 2019-05-20
Title of Research : Detection of norovirus among children under five years old with acute gastroenteritis and comparison of clinical features of norovirus and rotavirus gastroenteritis
Principle Investigator : Theingi Win Myat
Co-authors : Dr. Hlaing Myat Thu, Nang Sarm Hom
Field of Research : Gastroenterology
Publication Source : Myanmar Health Research Congress, 2018
Year of Publication : 2018
URL of Publication :
Presentation Source : 46th Myanmar Health Research Congress. 2018; P152
Placement of Presentation : Department of Medical Research
Year of Presentation : 2018
Abstract : Enteric viruses have been recognized as the most significant etiological agents of acute gastroenteritis (AGE) in children under five years old worldwide. Among enteric viruses, rotavirus (RV) is the commonest causal agent and norovirus (NoV) is next to RV. There is no study on detection of NoV and no baseline data in Myanmar although NoV is on the rising trend and of increasing global interest. This study, therefore, aims to investigate the proportion of diarrhea caused by NoV in children under five years old and compare the clinical features of NoV and RV gastroenteritis. From 820 stool samples collected and previously screened for RV in under-five children admitted to Yangon Children’s Hospital (YCH) for diarrhea between January and December 2016, 270 samples were randomly selected for detection of NoV by IDEIATM Norovirus EIA kit. NoV was detected in 10/270 (3.7%) and all positive cases were under 2 years of age, comprising 5/10 (50%) of 6-11 month and 5/10 (50%) of 12-23 month age groups. More males were infected with NoV than females accounting male to female ratio of 2.3:1. Proportion of RV positive cases accounted for 125/270 (46%) and the most affected age group was 6-11 month. Dual infection of RV and NoV was not found in this study. Compared with NoV infections, RV gastroenteritis cases had a significant higher percentage of fever (82% vs. 40%, p<0.05) and severe category of Vesikari scoring (80% vs. 50%, p<0.05). Dehydration was more common in RV infections (62% vs. 40%) and vomiting was more common in NoV infections (90% vs. 84%), however, these differences were not statistically significant. This information is the first and baseline data of NoV infection in under five years old children hospitalized for diarrhea in Myanmar. In countries where rotavirus vaccine has been introduced, the prevalence of RV infection is decreasing and NoV is taking place as the leading cause. Therefore, although percentage of NoV infection is low at present, surveillance is recommended to carry out alongside with RV to understand the disease pattern and changes in post rotavirus vaccination era and future norovirus vaccine development.
IRB/PRC/ERC Approval Date : 2017-07-31
Placement of IRB/PRC/ERC : Department of Medical Research
IRB/PRC/ERC Approval Letter/Document : Scan1.PDF
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -