Health Research Registry List

Research Registry No : HRID-00046_V8
 
University Departmental Research :
 
Registration Date : 2019-05-20
 
Title of Research : Surveillance of rotavirus gastroenteritis (2015-2017); vital information for pre-and post-rotavirus vaccination in Myanmar
 
Principle Investigator : Theingi Win Myat
 
Co-authors : Dr. Hlaing Myat Thu, Professor Ye Myint Kyaw, Dr. Nang Sarm Hom
 
Field of Research : Gastroenterology
 
Publication Source : Myanmar Medical Conference, 2018, P107
 
 
Year of Publication : 2018
 
URL of Publication : https://www.mmacentral.org/category/activities/conference/
 
Presentation Source : 64th Myanmar Medical Conference, 2018; P107
 
Placement of Presentation : 65th MMA Conference, MMA Central
 
Year of Presentation : 2018
 
Abstract : Hospital-based, prospective, active surveillance for rotavirus gastroenteritis (RVGE) was conducted to determine the proportion of rotavirus infection among acute gastroenteritis (AGE) cases and to identify rotavirus strains thereby providing information on epidemiology and strain diversity of RVGE. Stool samples were collected from children <5 years old admitted to Yangon Children’s Hospital (YCH) for AGE during January 2015 to September 2017, screened for rotavirus antigen by ELISA (ProSpecTTM Rotavirus) and genotyped by reverse transcription polymerase chain reaction. Overall, 1167/2393 (49%) of samples tested positive for rotavirus, ranging from 46-53% each year. The most affected was the 6-23 months age group, 956/1167 (81.9%) followed by 0-5 months 106/1860 (9.1 %) and 24-59 months 105/1167 (9.0%). RVGE occurred in a seasonal cycle with peak detection in the cold and dry months (November to February). As compared with non-RVGE, RVGE cases had significant higher percentage of vomiting (84.5% Vs 73%; P<0.05), fever (80.1% Vs 71.8%; P<0.05) and severe clinical scoring (79.3% Vs. 67.6%; P<0.05). Genotyping revealed that G9P[8] was predominant in the year 2015 (53.3%) and 2016 (30.9%), however, it was replaced in 2017 by G3P[8] (58.2%). Because of the high morbidity of RVGE, rotavirus vaccine is planning to introduce in Myanmar in the future, information from this surveillance not only highlights facts for consideration of target population, issues of dose scheduling and selection of appropriate vaccines in pre-vaccination era but also provide vital baseline data for post-vaccination monitoring of vaccine impact and effectiveness.
 
 
IRB/PRC/ERC Approval Date : 2015-12-11
 
Placement of IRB/PRC/ERC : Department of Medical Research
 
IRB/PRC/ERC Approval Letter/Document : 2016.PDF
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -