Health Research Registry List

Research Registry No : HRID-00054_V18
University Departmental Research :
Registration Date : 2019-06-03
Title of Research : Determination of Oncogenic Human Papillomavirus (HPV) Genotypes in Anogenital Cancers in Myanmar
Principle Investigator : Mu Mu Shwe
Co-authors : Hlaing Myat Thu, Khin Saw Aye, Aye Aye Myint, Mya Thida, Khin Shwe Mar, Khin Khin Oo, Shigeru Okada, Kyaw Zin Thant
Field of Research : Oncology
Publication Source : Acta Medica Okayama 2016; 70(2):103-110
Year of Publication : 2016
URL of Publication :
Presentation Source : 42nd Myanmar Health Research Congress 2014; p23.
Placement of Presentation : DMR
Year of Presentation : 2014
Abstract : Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identifi ed oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in Myanmar. In total, 100 biopsy tissues of histologically confi rmed anogenital cancers collected in 2008-2012 were studied, including 30 penile and 9 anal cancers from Yangon General Hospital and 61 vulvar cancers from Central Women’s Hospital, Yangon. HPV-DNA testing and genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism. Overall, 34 of anogenital cancers were HPV-positive. HPV was found in 44.4 of anal (4/9), 36.1 of vulvar (22/61), and 26.7 of penile (8/30) cancers. The most frequent genotypes in anal cancers were HPV 16 (75 ) and 18 (25 ). In vulvar cancers, HPV 33 was most common (40.9 ), followed by 16 (31.8 ), 31 (22.7 ), and 18 (4.6 ). In penile cancers, HPV 16 (62.5 ) was most common, followed by 33 (25 ) and 18 (12.5 ). This is the fi rst report of evidencebased oncogenic HPV genotypes in anogenital cancers among men and women in Myanmar. This research provides valuable information for understanding the burden of HPV-associated cancers of the anus, penis, and vulva and considering the eff ectiveness of prophylactic HPV vaccination.
IRB/PRC/ERC Approval Date : 2012-08-15
Placement of IRB/PRC/ERC : DMR
IRB/PRC/ERC Approval Letter/Document : ERC -32-2012.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -