Health Research Registry List

Research Registry No : HRID-00054_V19
University Departmental Research :
Registration Date : 2019-06-03
Title of Research : Molecular Detection of Oncogenic Human Papillomavirus (HPV) Genotypes in Vulva Cancers, Penile Cancers and Anal Cancers in Myanmar
Principle Investigator : Mu Mu Shwe
Co-authors : Hlaing Myat Thu, Aye Aye Myint, Mya Thida, Khin Shwe Mar, Khin Khin Oo, Khin Sandar Aye, Mo Mo Win, Kyaw Zin Thant
Field of Research : Oncology
Publication Source : Journal of Global Oncology 2016 (June); Meeting Proceedings p.1 (DOI:10.1200/JGO.2016.003814).
Year of Publication : 2016
URL of Publication :
Presentation Source : 4th Annual Symposium on Global Cancer Research, 8th April 2016; Oral Abstract p.36.
Placement of Presentation : San Francisco, USA
Year of Presentation : 2016
Abstract : Acausalroleforhumanpapillomavirus(HPV)associatedcancersofvulva,penile,andanusissupported by evidence from molecular and epidemiologic investigations. This study detected the oncogenic HPV genotypes in vulva cancers, penile cancers and anal cancers by a cross-sectional descriptive study in 2013.Atotalof100paraffinembeddedbiopsytissuesofhistologicallyconfirmedvulvacancers,penile cancersandanalcancerswithinpastfiveyearsduring2008and2012werestudied.Thosecaseswere 61vulvacancersfromCentralWomenHospital,Yangonand30penilecancersand9analcancersfrom Yangon General Hospital. HPV-DNA testing and genotyping were performed by polymerase chain reactionandrestrictionfragmentlengthpolymorphism(PCR-RFLP).Consensussequenceprimerpairs within the E6 andE7 open reading were used to amplify oncogenic HPV genotypes (HPV-16,-18,-31, -33,-35,-52b,-58). Restriction enzymes were used for determination of specific HPV genotypes. HPV was identified in 36.1% of vulva cancers (22/61), 26.7% of penile cancers (8/30) and 44.4% of anal cancers(4/9).Invulvacancers,HPV-33wasthemostcommongenotype(40.9%)followedbyHPV-16 (31.8%), HPV-31 (22.7%), and HPV-18 (4.6%). In penile cancers, HPV-16 (62.5%) was the most common genotype followed by HPV-33 (25%) and HPV-18 (12.5%). Among anal cancers, the most frequent genotypes were HPV-16 (75%) and HPV-18 (25%). This study is the first report of evidence based oncogenic HPV genotypes in vulva cancers, penile cancers and anal cancers in Myanmar. This research provides the valuable information in understanding the burden of HPV associated cancers of thevulva,penile,andanusinMyanmarandtheconsiderationoftheeffectivenessofprophylacticHPV vaccination in not only cervical cancer but also non-cervical cancers.
IRB/PRC/ERC Approval Date : 2012-08-15
Placement of IRB/PRC/ERC : DMR
IRB/PRC/ERC Approval Letter/Document : ERC -32-2012.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -