Health Research Registry List

Research Registry No : HRID-00104_V6
 
University Departmental Research :
 
Registration Date : 2019-05-30
 
Title of Research : Determination of T-2 Mycotoxin in Cereal-based Junk Foods sold from Some Food Stalls in Yangon Region
 
Principle Investigator : Thet Thet Mar
 
Co-authors : Thaung Hla, Zin Me Thein, Wai Lwin Oo
 
Field of Research : Others
 
Publication Source : Myanmar Health research Congress, 2016;P78-79
 
 
Year of Publication : 2015
 
URL of Publication : www.mhrc-mohs.com
 
Presentation Source : 44th Myanmar Health Research Congress. 2016
 
Placement of Presentation : Department of Medical Research, Yangon, Myanmar
 
Year of Presentation : 2016
 
Abstract : T-2 mycotoxin toxin (Tricothecene type A) is natural toxic secondary metabolite produced by certain species of Fusarium sporotrichioides, Fusarium poae, Fusarium equiseti and Fusarium acuminatum; microscopic filamentary fungi, which grow on various agricultural commodities in field, and or during post harvest period (transport, processing and storage). T-2 toxin is toxic to humans as well as animals and can penetrate or permeate through the human skin. The cellular effects of T-2 toxin are inhibition of DNA and RNA synthesis, apoptosis, effects on membranes and lipid peroxidation. The clinical condition it causes is alimentary toxic aleukia and a host of symptoms related to airborne intoxication and oral ingestion of moldy whole grains. The aim of the study is to find out the T-2 mycotoxin in cereal-based junk foods sold from food stalls. Cross-sectional laboratory based analytical study was conducted during the period from July to September 2015. Wheat, rice, corn, wheat and corn mixed, wheat, rice and corn mixed and wheat and rice mixed based foods samples, 55, 5, 4, 5, 7 and 6 respectively were collected from ten food stalls sold near the primary schools in Yangon region. A total of 82 samples were tested by using commercially available T-2 toxin ELISA test kit (Max signal). Forty six samples: 30 in wheat (54.55%), 2 in rice (40%), 2 in corn (50%), 5 in wheat:corn (100%), 5 in wheat:rice:corn (71.43%) and 2 in wheat:rice (33.33%) were contaminated with T-2 toxin at different levels ranging from 0.74 to 52.42 µg/kg ( 2-52.42 µg/kg in wheat, 0.74-2.13 µg/kg in rice, 2.55-21.59 µg/kg in corn, 1.82-12.67 µg/kg in wheat:corn, 1.17-19.08 µg/kg in wheat:rice:corn and 15.12-19.08 µg/kg in wheat:rice based samples). EU Scientific Committee on Food recommended the temporary tolerable daily intake (t-TDI) for T-2 toxin for human is 0.06μg/kg bodyweight. Even small doses, continuous consumption of T-2 toxin can lead to many health problems. It is an important public health issue. This study highlighted the awareness of the consumption of T-2 toxin contaminated cereal based foods in Myanmar.
 
 
IRB/PRC/ERC Approval Date : 2014-07-03
 
Placement of IRB/PRC/ERC : Department of Medical Research
 
IRB/PRC/ERC Approval Letter/Document : T2.pdf
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -