Health Research Registry List

Research Registry No : HRID-00134_V5
 
University Departmental Research :
 
Registration Date : 2019-05-17
 
Title of Research : Analgesic effect of rhizomes and leaves of Angiopteris evecta (Giant fern) on animal model
 
Principle Investigator : Phyo Wai zin
 
Co-authors : Khin Phyu Phyu, San San Htwe, Mya Marlar, Myo Nanda Aung, Zaw Myo Tint, Aye Win Oo, Mu Mu Sein Myint
 
Field of Research : Pharmacology
 
Publication Source :
 
 
Year of Publication : -
 
URL of Publication : -
 
Presentation Source : 46th Myanmar Health Research Congress. 2018; P40
 
Placement of Presentation : Department of medical research
 
Year of Presentation : 2018
 
Abstract : Plants are one of the sources of many modern drugs. Myanmar has many plants which have great medicinal values. Among them, Angiopteris evecta,Say-myin-khwar, is one of the traditional indigenous medicinal plants, which has many pharmacological properties such as antimicrobial activity, antihyperglycemic and hair growth activity. The aim of this study is to determine the analgesic effect of rhizomes and leaves of Angiopteris evecta(Giant fern) on albino mice. The plant material, Angiopteris evecta, was collected from Western Bago Yoma, Thabaung Township. The rhizomes and leaves of Angiopteris evecta were air-dried under shade for 7 days. Methanol extraction was done by soxhlet method. Yield percentage of rhizomes and leaves were 20.82 and 9.74 respectively. Acetic acid was used by intraperitoneally to cause pain in mice model and, the number of writhings produced was observed and recorded. The percent inhibitions of writhings were calculated in comparison to those of control. The standard analgesic, diclofenac, at the dose of 50 mg/kg body weight (Bwt) reduced the number of writhings by 61%. Methanolic extract of rhizomes at the dose of 100 mg/kg Bwt reduced the number of writhings by 30%; at the dose of 200 mg/kg Bwt by 8% and; at the dose of 400 mg/kg Bwt by 21% respectively. Methanolic extract of leaves at the dose of 100 mg/kg Bwt reduced the number of writhings by 24%; at the dose of 200 mg/kg Bwt by 35% and; at the dose of 400 mg/kg Bwt by 22 % respectively. Methanolic extract of leaves at the dose of 200 mg/kg Bwt showed statistically significant reduction of pain (p < 0.05) compared to control and had the best analgesic activity among the other dosages of rhizomes and leaves of Angiopteris evecta. However, both methanolic extracts of rhizomes and leaves showed no statistically significant analgesic effect (p ≥ 0.05) compared to the standard drug, diclofenac. In conclusion, methanolic extracts of rhizomes and leaves of Angiopteris evecta have analgesic activity which is about half of the activity of standard analgesic drug, diclofenac.
 
 
IRB/PRC/ERC Approval Date : 2016-09-26
 
Placement of IRB/PRC/ERC : Department of medical Research
 
IRB/PRC/ERC Approval Letter/Document : A evecta.pdf
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -