Health Research Registry List

Research Registry No : HRID-00136_V1
 
University Departmental Research :
 
Registration Date : 2019-05-17
 
Title of Research : Coagulation profile in type 2 diabetes mellitus patients attending the diabetic clinic, Yangon General Hospital
 
Principle Investigator : Myat Mon Oo
 
Co-authors : Moh Moh Htun, WIn Maw Tun, Ohnmar, Yin Min Htun, Hnin Nu Htwe, Mya Thandar Win, Kay Thwe Win
 
Field of Research : Pathology
 
Publication Source : Myanmar Health Sciences Research Journal. 2015; 27(1); P13-19
 
 
Year of Publication : 2015
 
URL of Publication : http://www.myanmarhsrj.com/file/display_fulltext.php?articleid=Reg-000039&issue=1&vol=27
 
Presentation Source : Myanmar Health Research Congress. 2014; Poster24
 
Placement of Presentation : Yangon
 
Year of Presentation : 2014
 
Abstract : Diabetes mellitus is a chronic disease that causes serious health complications including renal failure, heart disease, stroke and blindness. In Myanmar, the overall prevalence of diabetes mellitus was 12.6% of females and 11.5% of males. Type 2 diabetes mellitus patients had been known to have a hypercoagulable state and hypofibrinolysis. The coagulation profile, glycosylated hemoglobin (HbA1c) were determined in 187 patients with type 2 diabetes mellitus (44 males, 143 females, mean age 55±11 years) attending the diabetic clinic of Outpatient Department of Yangon General Hospital. In these patients, prothrombin time (PT) (12.2±1.4 sec), activated partial thromboplastin time (APTT) (32.2±4.7 sec), thrombin time (TT) (18.1±2.6 sec) were within normal ranges. One hundred and two (55%) patients have increased in fibrinogen concentration (4.2±1.3 g/l) just exceeded the upper limit (2-4 g/l). Fibrinogen concentration was significantly higher in female (4.4±1.2 g/l) than in male (4.0±1.3 g/l) (p<0.001). In diabetic patients with HbA1c levels more than 6.4%, mean fibrinogen concentration and TT were significantly increased ie., 4.4±1.3 g/l and 18.9±2.7 sec, respectively. Plasminogen activator inhibitor-1 (PAI-1) was measured in 77 diabetic patients with increased fibrinogen levels by using Human PAI-1 ELISA Kit. Forty-nine (64%) had PAI-1 level more than 50 ng/ml (references). PAI-1 level had positive correlation (r=0.29) with fibrinogen concentration in type 2 diabetes mellitus patients. The findings on coagulation status and fibrinolytic activity of type 2 diabetes mellitus patients would be beneficial for management of diabetic patients with thrombotic complications.
 
 
IRB/PRC/ERC Approval Date : 2012-10-01
 
Placement of IRB/PRC/ERC : Department of Medical Research
 
IRB/PRC/ERC Approval Letter/Document : img009.pdf
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -