Health Research Registry List

Research Registry No : HRID-00192_V15
University Departmental Research : No
Registration Date : 2020-04-01
Title of Research : Evaluation of Dengue infection diagnosis by detection with NS1 antigen, IgM and IgG antibodies in patients with acute febrile illnesses
Principle Investigator : Moe Kyaw Myint
Co-authors : May Thet Naing, Khin Lin, Aung Thu, Mya Moe, Win Htay Hlaing, Aung Kyaw Soe & Kyaw Zin Thant
Field of Research : Virology
Publication Source :
Year of Publication : -
URL of Publication : -
Presentation Source : 16th Mandalay Medical Conference. 2017; P39
Placement of Presentation : Myanmar Medical Association, Mandalay
Year of Presentation : 2017
Abstract : In district areas of Myanmar, early diagnosis and good supportive care are crucial management for dengue cases. Laboratory confirmation with dengue diagnostic test kit is important due to difficulties in making accurate diagnosis because of having wide spectrum of clinical presentations. This study aimed to evaluate the rapid diagnostic testing of dengue NS1 antigen, IgG and IgM antibody among the patients with acute febrile illnesses. It was Laboratory and hospital based cross-sectional descriptive study conducted in 2014 and 2015. Total of 419 paediatric patients with acute febrile illness diagnosed as dengue infection according to WHO guidelines were included in the study. Among them, 54.7% were male and 72.8% were from urban area. Mean age (±SD) of patients was 7.1 (±3.4) in years. The youngest was 1 and oldest was 13 years. Clinical features; fever, vomiting, abdominal pain, musculoskeletal pain, restlessness, rash and hepatomegaly were observed in 91.2%(382/419), 49.2%(206/419), 32.5%(136/419), 17.2%(72/419), 18.6%(78/419), 9.3%(39/419) and 9.1%(38/419) of the patients, respectively. Laboratory findings of increased haematocrit, positive tourniquet test, thrombocytopenia and leucopenia were examined in 33.2%(139/419), 54.2%(227/419), 35.6%(36/101), 20.2%(45/223) and 26.9%(59/219) of patients, respectively. NS1 antigen, IgG and IgM were detected in 96(22.9%), 60(14.3%) and 64(15.3%) patients, respectively. At least one positive detection of 3 rapid diagnostic tests was observed in 37.2%(121/287) of patients with clinical features of DF or DHF infection according to WHO classification (p=0.003). Therefore, these rapid diagnostic tests have limited sensitivity and confirmatory diagnosis should be made jointly with clinical sign and symptom, and other laboratory findings.
IRB/PRC/ERC Approval Date : 2014-05-08
Placement of IRB/PRC/ERC : ERC DMR-UM
IRB/PRC/ERC Approval Letter/Document : 01042020045319img-311131450.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -