Health Research Registry List

Research Registry No : HRID-00192_V17
University Departmental Research : No
Registration Date : 2020-04-02
Title of Research : Epidemiological factors associating with malarial antibody prevalence
Principle Investigator : Moe Kyaw Myint
Co-authors : Khin Lin, Aung Thu, Mya Moe, Phyu Phyu Win, Zaw Lin, Kyaw Zin Thant
Field of Research : Public Health
Publication Source : Myanmar Health Sciences Research Journal. 2018; 30(1): P15-20
Year of Publication : 2018
URL of Publication : -
Presentation Source : 42nd Myanmar Health Research Congress. 2014; P34
Placement of Presentation : DMR, Yangon
Year of Presentation : 2014
Abstract : Malaria antibodies have been associated with transmission intensity and antibody responses are not much varied in seasonal condition. Antibody assessment is probable to provide useful epidemiology tool. This study aimed to detect prevalence of antibody in different risk areas in different seasons. Community based cross-sectional descriptive study was conducted at high risk areas and moderate risk areas during rainy and dry season in 2012-2013. Rapid diagnostic testing was used for examination of antigens and antibodies. Microscopic examinations were done. Among total 414 participants, male were 279(67.4%) and female were 135(32.6%). Mean age was 32.1±14.1 (year). Malaria antigens and antibodies (P.falciparum/P.vivax) were detected in 17.9%(74) and 19.1%(79) of participants, respectively. Participants with old age (mean=35±12.7 year) had more prevalence of antibody than younger aged participants (mean=31.4±14.4 year). Mean difference was 3.6 years (p=0.040). Antibody prevalence was higher in participants of high risk areas (20.4%) than participants of moderate risk areas(17.6%). Variation of antibody prevalence between rainy and dry season was less than that of antigen prevalence. In high risk areas, antibody was 25.5% in rainy season and 10.4% in dry season. Antigen prevalence had much variation with 32.9% in rainy season compared to 5.2% in dry season in high risk area. However, in moderate risk areas, antibody prevalence was 17.7% in rainy season and it remained with 16.7% in dry season. The antigen prevalence was 13.3% in rainy season and it was (0%) not found in dry season in moderate risk areas. Therefore, less seasonal variation of antibody between rainy and dry season was observed in moderate risk areas. The study concluded that protective effects of malaria antibody were observed in older age and associated with transmission intensity. Therefore, antibody assessment can probably provide useful epidemiology tool as it has less seasonal variation.
IRB/PRC/ERC Approval Date : 2014-05-08
Placement of IRB/PRC/ERC : ERC DMR-UM
IRB/PRC/ERC Approval Letter/Document : 02042020071800malAb.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -