Health Research Registry List

Research Registry No : HRID-00305_V3
University Departmental Research :
Registration Date : 2019-05-30
Title of Research : Histological identification of Helicobacter pylori in colorectal cancer by Immunohistochemistry
Principle Investigator : Aye Aye Win
Co-authors : Yi Yi Kyaw, Yin Min Htun, Hnin Nu Htwe, Kay Thwe , Moh Moh Htun
Field of Research : Pathology
Publication Source :
Year of Publication : -
URL of Publication : -
Presentation Source : 44th Myanmar Health Research Congress. 2016; P89
Placement of Presentation : Department of Medical Research
Year of Presentation : 2016
Abstract : Most colorectal cancer occurs due to lifestyle and increasing age with only a minority of cases associated with underlying genetic disorders. Helicobacter pylori is one of the evidence on four infectious agents that have been most commonly studied in relation to colorectal cancer. Despite the established relationship between H.pylori and gastric pathologies, the association between H.pylori and colorectal cancer is much less clear. In this study, with the aim of to know the potential relationship of the presence of H.pylori and colorectal cancer, H.pylori was identified in formalin fixed paraffin embedded colorectal cancer tissues by immunohistochemistry method using Dako, polyclonal rabbit anti H.pylori Ab assay kit. A total of 47 colorectal cancer tissue samples, histologically diagnosed as adenocarcinoma were collected from Department of Pathology, YGH during 2012 to 2013. The ages of the patients ranged from 24 to 72 years. The most common age group is 50 to 59 years comprising 13 cases (28%). In this study, 23 males and 24 females were included in the ratio of 1:1. Only 3 well differentiated adenocarcinoma cases (0.06%) found at sigmoid colon were identified H. pylori. Therefore, in this study, the finding was concluded that there was no significant association between the presence of H.pylori and colorectal cancer (P>0.05). But there were some limitation in the study size and method used. So it was suggested the future research using larger sample size and more sensitive method like PCR which can reflect whether its presence is a risk factor for colorectal cancer.
IRB/PRC/ERC Approval Date : 2013-09-03
Placement of IRB/PRC/ERC : Department of Medical Research
IRB/PRC/ERC Approval Letter/Document : H pylor.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -