Health Research Registry List

Research Registry No : HRID-00305_V4
University Departmental Research :
Registration Date : 2019-05-30
Title of Research : Study on presence of macrophages in cervical cancer using immunohistochemistry
Principle Investigator : Aye Aye Win
Co-authors : Mu Mu Shwe, Min Thein, Khin Saw Aye, Tin Tin Han, Khin Than Maw, Thazin Myint, Khin Shwe Mar
Field of Research : Pathology
Publication Source : Myanmar Health Services Research Journal. 2012; 24(1)25-29
Year of Publication : 2012
URL of Publication : -
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Abstract : It was a cross-sectional, hospital- and laboratory-based descriptive study aimed to study the presence of macrophages in cervical cancer using immunohistochemistry. A total of 55 formalin-fixed, paraffin-embedded cervical cancer tissues were collected from Pathology Department, CWH from January, 2009 to December, 2009. Routine haematoxyline and eosin stain was performed to confirm the diagnosis. Among them, 12 cases (21.8%) were diagnosed as well differentiated squamous cell carcinoma (SCC), 23 cases (41.8%) were moderately differentiated SCC and the rest 20 cases (36.4%) were poorly differentiated SCC. Then, immunohisto-chemical stain for macrophage marker (CD68) was done. High intensity of CD68 was found in 4 cases (33%) of WDSCC, 10 (43%) of MDSCC and 7 (35%) of PDSCC; moderate intensity in 8 cases (67%) of WDSCC,8 cases (35%) of MDSCC and 9 cases (45%) of PDSCC; low intensity in 5 cases (22%) of MDSCC and 4 cases (20%) of PDSCC. The correlation of CD68 intensity with the staging of cancer cervix was also examined. High and moderate intensity was mainly found in advanced stages (Stage III and IV). In this study, we concluded that there was no significant correlation between the intensity of macrophage marker (CD68) with the histological grade (p=0.358) and clinical staging (p=0.201) in cancer cervix. The findings agreed with those of other studies done in squamous cell carcinoma cervix which highlighted that the beneficial role of macrophages in cellular immunity may be opposed by the elaboration of growth factors in the vicinity of neoplastic cells.
IRB/PRC/ERC Approval Date : 2006-12-21
Placement of IRB/PRC/ERC : Department of Medical Research
IRB/PRC/ERC Approval Letter/Document : CD 68.pdf
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