Health Research Registry List

Research Registry No : HRID-00338_V2
University Departmental Research :
Registration Date : 2019-05-17
Title of Research : Hair growth activity of Angiopteris evecta in rabbit
Principle Investigator :
Co-authors : Phyo Wai Zin, Khine Khine Lwin, Khin Phyu Phyu
Field of Research : Pharmacology
Publication Source : Myanmar Health Sciences Research Journal. 2018; 29(1): P80-85
Year of Publication : 2018
URL of Publication :
Presentation Source : 46th Myanmar Health Research Congress. 2018; P2)
Placement of Presentation : DMR
Year of Presentation : 2018
Abstract : One of the problems often experienced by humans is baldness or hair growth that is not normal. Angiopteris evecta (Say-myin-khwar) is one of the traditional indigenous medicinal plants which have many pharmacological properties. The aim of the study was to detect the skin irritation activity and to determine hair growth activity of the watery and ethanol extracts of Angiopteris evecta on rabbit. Six male albino rabbits were used as test animals. Each rabbit was sheared back and divided into four plots, one for negative control, one for standard 2% minixidol and the others two were tested extracts. Each plot has a size of 2 x 2 cm. One mL of different concentration of 10%, 20% and 40% watery and ethanol extracts was given 2 times per day consecutively for 18 days. Measurement of rabbit hair length was done on every 3 days. Five strands of hair were used to measure the length and average lengths of the five strands were calculated. The results of skin irritation showed that the irritation degree was categorized as negligible. Mean length of hair growth for negative control was 0.74 cm and that of standard 2% minoxidil was 1.5 cm. Mean length of hair growth at doses of 10 %, 20 % and 40 % of watery extract were 0.82 cm, 1.28 cm and 1.4 cm, respectively. For ethanolic extract, mean length of hair growth for doses of 10 %, 20 % and 40 % were 0.81 cm, 1.29 cm and 1.39 cm, respectively. The rabbit treated with watery and ethanolic extract of Angiopteris evecta (Say-myin-khwar) showed increased in hair length when compared with those of control group (p<0.01). Hair growth activity of 40% watery and 40% Ethanolic extract of Angiopteris evecta were compared with standard 2% minoxidil and there was no statistically significant difference between the two test groups and standard group. Therefore, hair growth activity of watery and ethanol extract were as comparable with standard 2% minoxidil.
IRB/PRC/ERC Approval Date : 2016-09-26
Placement of IRB/PRC/ERC : 060/16
IRB/PRC/ERC Approval Letter/Document : IMG_0002.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -