Health Research Registry List

Research Registry No : HRID-00362_V3
University Departmental Research :
Registration Date : 2019-05-22
Title of Research : Antioxidant activity of betel leaf (Piper betle Linn.)
Principle Investigator : May Thandar Htun
Co-authors : Wai Mi Aung, Aye Aye Phyu, Aye Thida Htun, Swe Zin Aung, Zin Nwe Soe, Swe Swe, Yi Yi Myint
Field of Research : Pharmacognosy
Publication Source : Myanmar Health Sciences Research Journal. 2015; 27(3): P205-210
Year of Publication : 2015
URL of Publication :
Presentation Source : 43rd Myanmar Health Research Congress. 2015; P24
Placement of Presentation : Department of Medical Research (Head Quarter)
Year of Presentation : 2015
Abstract : Piper betle L. belongs to the family Piperaceae is an evergreen and perennial creeper with glossy heart-shaped leaves and white catkin. The leaves of Piper betle L. have been traditionally known for its various therapeutic uses such as stimulant, antitussive, carminative, expectorant, anti-hyperglycemic, antibacterial and antifungal. In the present study, the leaves of Piper betle L. were collected from cultivated sources in Kyaukse Township, Mandalay region. Botanical identification of plant was done by morphological examinations. Phytochemical characters were studied by using reference analytical methods. The different extracts were obtained by percolation and reflux method. Antioxidant activities of fresh juice, ethanol extract and aqueous extract of Piper betle L. was determined by using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and ascorbic acid was used as specific standard. While IC50 of ascorbic acid was 1.66 µg/mL, the concentration of Piper betle L. needed for 50% inhibition (IC50) was found to be 0.092 mg/mL, 0.094 mL/mL, 0.095 mg/mL for ethanol extract, fresh juice and aqueous extract respectively. Ethanol extract of Piper betle L. possessed more antioxidant activity than fresh juice and aqueous extract. From above data, Piper betle L. possess antioxidant activity which demonstrates the possibility of the use of this plant as supplementary medicine.
IRB/PRC/ERC Approval Date : 2014-08-22
Placement of IRB/PRC/ERC : Department of Medical Research (Pyin Oo Lwin Branch)
IRB/PRC/ERC Approval Letter/Document : Betel agreement.pdf
Pre-existing Registration ID : -
Pre-existing Name of Organization : -
Pre-existing Website : -