Health Research Registry List

Research Registry No : HRID-00393_V5
 
University Departmental Research :
 
Registration Date : 2019-05-17
 
Title of Research : Detection of monoclonal gammopathies in chronic low back pain patients at Yangon Orthopaedic Hospital
 
Principle Investigator : San San Htwe
 
Co-authors : Thit Lwin
 
Field of Research : Orthopedics
 
Publication Source : --
 
 
Year of Publication : -
 
URL of Publication : --
 
Presentation Source : 44th Myanmar Health Research Congress. 2016; P92)
 
Placement of Presentation : Department of Medical Research
 
Year of Presentation : 2016
 
Abstract : The monoclonal gammopathies (paraproteinaemias) are a group of disorders associated with monoclonal proliferation of plasma cells. They are characterized by the secretion of electrophoretically and immunologically homogeneous monoclonal (M) protein. The M protein is a tumor marker specific for monoclonal gammopathies because it reflects the clonal production of immunoglobulin. The aim of the study is to find out how much monoclonal gammopathies is common in chronic low back pain patients. It was conducted at Yangon Orthopaedic Hospital on chronic low back pain patients who fulfilled the selection criteria. A total of 87 patients were included in the study. Serum protein electrophoresis was performed on cellulose acetate strip. M band was detected visually and concentration of M protein was estimated by densitometer. Among the 87 cases, 15 cases (17.24%) had monoclonal gammopathy and were referred to Department of Clinical Haematology, Yangon General Hospital. Age of the patients ranged from 45 years to 74 years. The male to female ratio was 0.7:1. Among these cases, 13(14.94%) had the M band in the gamma () region and 2 cases (2.3%) had it in the beta () globulin region. The mean concentration of the M protein was 3.11g/dl, with a range of 1.72 to 4.46 g/dl. The findings of the study reported the occurrence of monoclonal gammopathy among chronic low back pain patients and serum protein electrophoresis can be used for detection and quantification of monoclonal gammopathy and should be recommended as a screening test among low back pain patients.
 
 
IRB/PRC/ERC Approval Date : 2013-05-03
 
Placement of IRB/PRC/ERC : Department of Medical Research
 
IRB/PRC/ERC Approval Letter/Document : MGLBP_ERC.pdf
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -