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Research Registry No |
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HRID-00393_V7 |
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University Departmental Research |
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Registration Date |
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2019-05-17 |
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Title of Research |
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Identification of immunological markers in pulmonary tuberculosis patients attending a Township Health Department, Yangon Region |
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Principle Investigator |
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San San Htwe |
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Co-authors |
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Wai Sint Kyaw , Aye Mya Khine, Khin La Pyae Tun, Moh Moh Hlaing, Aye Thandar Khaing, Tin Mi Mi Khaing , Win Pa Pa Naing, Khin Saw Aye |
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Field of Research |
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Immunology |
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Publication Source |
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-- |
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Year of Publication |
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- |
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URL of Publication |
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Presentation Source |
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47th Myanmar Health Research Congress. 2019; P173 |
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Placement of Presentation |
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Department of Medical Research |
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Year of Presentation |
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2019 |
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Abstract |
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Pulmonary tuberculosis is a common disease in developing countries and remains the leading cause of morbidity and mortality from infectious disease worldwide. Protective cellular immunity against TB is mediated by CD4 T-lymphocytes with support from CD8 T-lymphocytes. The application of flow cytometry has hugely advanced the field of tuberculosis across all areas of research ranging from diagnostic tests to understanding the underlying immunology. Determining the extent of immune cells belonging to cell mediated immunity is critical to maximize the potential benefit of antitubercular treatment and case management. A cross sectional comparative study was conducted to identify immunological markers (CD4, CD8) in pulmonary TB patients before and after initial two months of anti-TB treatment. A total of 30 pulmonary tuberculosis patients (19 males and 11 females) were enrolled from Department of Public Health, Hlaing Township. All patients enrolled in the study were negative for human immunodeficiency virus (HIV). Immunological markers were determined by multicolour flow cytometry CyFlowÒ Cube 8 (Sysmex Partec).The mean age of 39.77± 14.53 years (20 - 70 years) was included. Mean CD4 count of pulmonary TB patients after initial two months of anti-TB treatment (711 ± 158 cells/ μl) was significantly higher than pulmonary TB patients before treatment (532 ± 147 cells/ μl) (p<0.001). Similarly, mean CD8 count of pulmonary TB patients after initial two months of anti-TB treatment (405 ± 73 cells/ μl) was significantly higher than pulmonary TB patients before treatment (332 ± 93 cells/ μl) (p<0.001).The study demonstrated that cell mediated immunity was altered in pulmonary tuberculosis and anti-tuberculous chemotherapy was effective in reversing this condition after two months. |
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IRB/PRC/ERC Approval Date |
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2017-12-01 |
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Placement of IRB/PRC/ERC |
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Department of Medical Research |
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IRB/PRC/ERC Approval Letter/Document |
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TB_ERC.pdf
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Pre-existing Registration ID |
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- |
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Pre-existing Name of Organization |
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Pre-existing Website |
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