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Research Registry No |
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HRID-00399_V1 |
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University Departmental Research |
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Registration Date |
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2019-05-17 |
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Title of Research |
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Determination of Antioxidant Activities and Bioactive Components of
Foeniculum vulgare Mill. ((Samonsabar - ) |
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Principle Investigator |
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Lei lei Win |
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Co-authors |
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Field of Research |
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Pharmacology |
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Publication Source |
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Myanmar Health Sciences Research Journal. 2019; 29(1): P80-85 |
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Year of Publication |
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2019 |
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URL of Publication |
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www.myanmarhsrj.com |
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Presentation Source |
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45th Myanmar Health Research Congress. 2017; P1-5 |
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Placement of Presentation |
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Department of Medical Research (Head Quarter) |
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Year of Presentation |
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2017 |
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Abstract |
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World Health Organization (WHO) estimated that 80% of the population of
developing countries use traditional medicines, mostly natural plant
products, for their primary health care needs. In the past few decades, the
medicinal value of plants has been assumed more important dimension
owing largely to the discovery that extracts from plants contain not only
primary metabolites but also a diverse array of secondary metabolites with
antioxidant potential. Medicinal plants are potential sources of natural
compounds with biological activities and therefore attract the attention of
researchers worldwide. Antioxidants are vital substances which possess
ability to protect the body from damage due to free radical inducedoxidative stress. The purpose of current study was to determine the
antioxidant activities and bioactive components of Foeniculum vulgare
(fennel) (Samonsabar) seeds by using UV Visible Spectrophotometer
(UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Aqueous
extract of fennel seeds showed more antioxidant activity (IC50: 0.28 ug/ml)
than ethanolic extract (IC50: 0.83 ug/ml) and comparable to standard
antioxidant, ascorbic acid (IC50: 0.59 ug/ml). GC-MS analysis was fruitful in
identification of compounds based on peak area, retention time, molecular
formula, molecular weight, MS Fragmentions and pharmacological actions.
Ten bioactive phytochemical compounds from aqueous extracts and 11 from
ethanolic extract of fennel seeds were identified. These findings indicated
that fennel seeds are potential to provide preventive properties against
oxidative damage. These results will give scientific information for quality
control of indigenous drug to herbal medicine users and local practitioners
using fennel for different types of ailments.
Key words: Antioxidant activity, Bioactive components, Foeniculum vulgare Mill, UV Visible
Spectrophotometer, Gas Chromatography-Mass Spectrometry |
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IRB/PRC/ERC Approval Date |
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2015-09-10 |
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Placement of IRB/PRC/ERC |
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Department of Medical Research (POLB) |
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IRB/PRC/ERC Approval Letter/Document |
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2015 PRC No.pdf
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Pre-existing Registration ID |
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- |
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Pre-existing Name of Organization |
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- |
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Pre-existing Website |
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