Health Research Registry List

Research Registry No : HRID-00405_V3
 
University Departmental Research :
 
Registration Date : 2019-05-30
 
Title of Research : Hepatitis B and C Virus Genotypes among Patients with Chronic Liver Diseases in Myanmar; Multiple Genotypes and Subtypes of Hepatitis B and C Viruses
 
Principle Investigator : Yi Yi Kyaw
 
Co-authors : Hnin Ohnmar Soe, Aye Aye Lwin, Kay Thi Aye, Win Naing, Naing Naing Htun, Hlaing Myat Thu, Chulhun L Chang, Jae Hun Cheong
 
Field of Research : Virology
 
Publication Source : Laboratory Medicine Congress and Exhibition 2018 & 59th Annual Meeting of Korea society of laboratory medicine proceeding book.Page 122
 
 
Year of Publication : 2018
 
URL of Publication : -
 
Presentation Source : Laboratory Medicine Congress and Exhibition 2018 & 59th Annual Meeting of Korea society of laboratory medicine proceeding book.Page 122
 
Placement of Presentation : Grand Walkerhill hotel, Seoul, Korea
 
Year of Presentation : 2018
 
Abstract : Background : Our recent nation-wide study in 2015 reported a seroprevalence of 6.5% for hepatitis B virus (HBV) and 2.6% for hepatitis C virus (HCV), but little is known about the molecular characteristics of circulating viruses from HBV and HCV infected chronic liver diseases patients. Methods : This study analyzed 67 patients positive for HBV surface antigen (HBs Ag), and 58 patients positive for anti-HCV chronic liver diseases, who attend at Hepatitis Carrier Clinic and 500 Bedded Specialist Hospital, Yangon, Myanmar. Phylogenetic analysis of 6 complete genomes and 61 partial HBV sequences, as well as 58 partial HCV sequences revealed that multiple genotypes and subtypes of both viruses are circulating in Myanmar. Results: Of the HBV strains, 37.3% were genotype HBV/D and 62.7 % were genotype HBV/C. The genotype HBV/D was seen only in chronic hepatitis B patients, and all cirrhosis and hepatocellular carcinoma cases showed HBV/C genotypes. HBV genotypes have distinct geographical distributions and correlate with the severity of liver disease. HBV genotype C is known to be more virulent and is associated with poor clinical outcome. Our data would support the clinical relevance of HBV genotypes in Myanmar. Moreover, the 58 HCV strains belong to genotype 6 variants (41.4%), subtype 3b (36.2%), genotype 1 variants (20.7%) and type 2 (1.7%). According to previous report of Myanmar, HCV genotypes 1, 3 and 6 were observed in voluntary blood donors in Yangon. Conclusions: In the present study, genotype 6 is the most prevailing genotypes in HCV positive chronic liver diseases patients. In the era of direct acting antiviral against HCV, there is an increasing need to identify HCV genotypes to support treatment strategies. keywords: hepatitis B, hepatitis C, genotypes, subtypes, Myanmar
 
 
IRB/PRC/ERC Approval Date : 2014-02-11
 
Placement of IRB/PRC/ERC : Department of Medical Research
 
IRB/PRC/ERC Approval Letter/Document : molecular characterization.pdf
 
Pre-existing Registration ID : -
 
Pre-existing Name of Organization : -
 
Pre-existing Website : -