Health Research Registry List

Research Registry No : HRID-00527_V1
 
University Departmental Research :
 
Registration Date : 2019-10-24
 
Title of Research : Myositis antibody profiles and clinico-pathological association in patients with idiopathic inflammatory myositis at Tertiary hospital, Myanmar
 
Principle Investigator : WIN MIN THIT
 
Co-authors : CHO CHO NYUNT, CHIT SOE, OHNMAR, ZIN PHYU TUN, CHO MAR LWIN, YIN MINN SOE, SU LE HTAY, SOE LIN OO
 
Field of Research : Neurology
 
Publication Source : =
 
 
Year of Publication : -
 
URL of Publication : =
 
Presentation Source : 18th Asian And Oceanian Myology Center (AOMC) Meeting Conference (31 May-02 Jun 2019) in Mumbai, India (Poster presentation)
 
Placement of Presentation : Mumbai, India
 
Year of Presentation : 2019
 
Abstract : Objective: to determine the distribution of various IIM and their profile at the largest tertiary hospitals in Myanmar. Method: It was a hospital based descriptive study recruiting IIM patients admitted to Neurology and Rheumatology ward over a 1.5 year period from September 2017 to February 2019. Results: Among total 51 IIM patients recruited, 32 patients (62.7%) presented to Neurology ward and 19 (37.3%) to Rheumatology ward. Overlap myositis (OM) was the commonest (43%), followed by necrotizing autoimmune myopathy (NAM) 27%, dermatomyositis (DM) 24%, polymyositis (PM) 6%. Among OM, anti-Synthetase syndrome (ASS) was 23%, and among NAM, anti-SRP positive was 79%. NAM and PM patients presented more to neurologists while OM and DM more to Rheumatologists. 82% were females (M:F= 4.6:1). Mean age of onset of myositis was 40.2 + 17.8 years, and duration of symptoms before presentation was 10-3600 days (shortest in anti-SRP and longest in anti-HMGCR myopathy). Myositis antibodies were positive in 67% of IIM cases. CK range was 40-25690 U/l, highest in NAM subtype and lowest in DM cases. Associated connective tissue diseases among OM in order of descending frequency were 47% Systemic lupus erythematosus, 24% Sjogren syndrome, 41% Scleroderma and 12% Rheumatoid arthritis. Associated cancer identified were one lung cancer in DM, one breast cancer in OM, one buccal cancer in NAM cases. Conclusions: With recent availability of myositis antibody panel and MHC staining in Myanmar, we have applied current updated classification to describe the first Myanmar data on idiopathic inflammatory myositis cases.
 
 
IRB/PRC/ERC Approval Date : 2018-12-05
 
Placement of IRB/PRC/ERC : University of Medicine 1
 
IRB/PRC/ERC Approval Letter/Document : File.PDF
 
Pre-existing Registration ID : 089/UM1,REC.2018
 
Pre-existing Name of Organization : Department of Neurology, University of Medicine 1
 
Pre-existing Website : =